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3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative hallucinogen of the arylcyclohexylamine class related to phencyclidine (PCP) that has been sold online as a designer drug.

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Buy 3-HO-PCP Powder Online

3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative hallucinogen of the arylcyclohexylamine class related to phencyclidine (PCP) that has been sold online as a designer drug.3-HO-PCP acts as a high-affinity uncompetitive antagonist of the NMDA receptor via the dizocilpine (MK-801) site (Ki = 30 nM). It has much higher affinity than PCP for this site (Ki = 250 nM, for comparison; 8-fold difference).The drug also has high affinity for the μ-opioid receptor (MOR) (Ki = 39–60 nM),the κ-opioid receptor (KOR) (Ki = 140 nM),and the sigma σ1 receptor (Ki = 42 nM; IC50 = 19 nM),whereas it has only low affinity for the δ-opioid receptor (Ki = 2,300 nM).The high affinity of 3-HO-PCP for opioid receptors is unique among arylcyclohexylamines and is in contrast to PCP, which has only very low affinity for the MOR (Ki = 11,000–26,000 nM; 282- to 433-fold difference) and the other opioid receptors (Ki = 4,100 nM for the KOR and 73,000 nM for the DOR).Buy 3-HO-PCP Powder Online
Although it was hypothesized that 3-HO-PCP might be a metabolite of PCP in humans, there is no evidence that this is the case.3-HO-PCP is an arylcyclohexylamine.Close analogues of 3-HO-PCP include PCP, 3-MeO-PCP, 4-MeO-PCP, 3-MeO-PCMo, and somewhat more distantly ketamine, methoxyketamine, 3-MeO-PCE, and methoxetamine. A cannabinoid is one of a class of diverse chemical compounds that acts on cannabinoid receptors, also known as the endocannabinoid system in cells that alter neurotransmitter release in the brain. Ligands for these receptor proteins include the endocannabinoids produced naturally in the body by animals; phytocannabinoids, found in cannabis and some other plants; and synthetic cannabinoids, manufactured artificially. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis.Cannabidiol (CBD) is another major constituent of the plant.There are at least 113 different cannabinoids isolated from cannabis, exhibiting varied effects.Synthetic cannabinoids encompass a variety of distinct chemical classes: the classical cannabinoids structurally related to THC, the nonclassical cannabinoids (cannabimimetics) including the aminoalkylindoles, 1,5-diarylpyrazoles, quinolines, and arylsulfonamides as well as eicosanoids related to endocannabinoids.Buy 3-HO-PCP Powder Online
Medical uses include the treatment of nausea due to chemotherapy, spasticity, and possibly neuropathic pain.[5] Common side effects include dizziness, sedation, confusion, dissociation and “feeling high”.Before the 1980s, it was often speculated that cannabinoids produced their physiological and behavioral effects via nonspecific interaction with cell membranes, instead of interacting with specific membrane-bound receptors. The discovery of the first cannabinoid receptors in the 1980s helped to resolve this debate.These receptors are common in animals, and have been found in mammals, birds, fish, and reptiles. At present, there are two known types of cannabinoid receptors, termed CB1 and CB2,with mounting evidence of more.The human brain has more cannabinoid receptors than any other G protein-coupled receptor (GPCR) type.CB1 receptors are found primarily in the brain, more specifically in the basal ganglia and in the limbic system, including the hippocampus and the striatum. They are also found in the cerebellum and in both male and female reproductive systems. CB1 receptors are absent in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular functions. CB1 is also found in the human anterior eye and retina.CB2 receptors are predominantly found in the immune system, or immune-derived cellswith the greatest density in the spleen. While found only in the peripheral nervous system, a report does indicate that CB2 is expressed by a subpopulation of microglia in the human cerebellum.CB2 receptors appear to be responsible for the anti-inflammatory and possibly other therapeutic effects of cannabis seen in animal models.Buy 3-HO-PCP Powder Online

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